5-Oxo-1-(phenylmethyl)-L-proline 1,1-dimethylethyl ester - Names and Identifiers
Name | L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimethylethyl ester
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Synonyms | 1-Benzyl-5-oxo-L-proline tert-butyl ester (S)-tert-butyl 1-benzyl-5-oxopyrrolidine-2-carboxylate tert-Butyl (S)-1-benzyl-5-oxopyrrolidine-2-carboxylate 5-Oxo-1-(phenylmethyl)-L-proline 1,1-dimethylethyl ester tert-butyl (2S)-1-benzyl-5-oxo-pyrrolidine-2-carboxylate L-Proline,5-oxo-1-(phenylMethyl)-, 1,1-diMethylethyl ester L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimethylethyl ester
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CAS | 90741-27-8
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5-Oxo-1-(phenylmethyl)-L-proline 1,1-dimethylethyl ester - Physico-chemical Properties
Molecular Formula | C16H21NO3
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Molar Mass | 275.34 |
Melting Point | 73-74℃ |
Storage Condition | 2-8°C |
5-Oxo-1-(phenylmethyl)-L-proline 1,1-dimethylethyl ester - Introduction
L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimethylethyl ester, also known as L-proline tert-butyl ester, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Molecular formula: C17H23NO3
-Molecular weight: 293.37g/mol
-Appearance: White crystalline powder or solid
-Melting point: 85-87°C
-Boiling point: 437.5°C
-Solubility: Soluble in alcohol, ketone and ether, slightly soluble in water
Use:
- L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimethylethyl ester is widely used in the field of organic synthesis, especially in the fields of inorganic chemistry, medicinal chemistry and biochemistry.
-It can be used as a catalyst precursor for chiral catalysts, and can be used for asymmetric synthesis and preparation of chiral compounds.
-It can also be used for the preparation of drug intermediates and the synthesis of drug molecules.
Method:
L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimethylethyl ester can be synthesized by the following steps:
1. Condensation reaction of L-proline and tert-butyl alcohol was carried out under alkaline conditions to obtain L-proline tert-butyl ester.
2. transesterification of the obtained product with tert-butyl chloroformate to produce the final product L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimethylethyl ester.
Safety Information:
- L-Proline, 5-oxo-1-(phenylmethyl)-, 1,1-dimenthylethyl ester is generally safe under normal conditions of use, but appropriate safety measures still need to be taken.
-Wear protective gloves, goggles and protective clothing when using.
-Avoid contact with skin and eyes, such as accidental contact, immediately rinse with plenty of water. If you feel unwell, seek medical help.
-Avoid inhalation or ingestion of the substance.
-use or storage should be away from fire and high temperature environment.
Last Update:2024-04-09 15:18:00